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Medicines (732)

Medicines > generic: None

& classes: GABA-A positive allosteric modulator

& routes: Intravenous (continuous infusion in a REMS-certified facility)

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Zulresso (1)

None (1)

Postpartum depression (PPD) in adults (1)

Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h (1)

100 mg/20 mL vial, single-use (1)

Single 60-hour course (1)

Antidepressant effect within hours of infusion start; sustained at 30 days (1)

Single infusion course (1)

~9 hours (terminal) (1)

100% (IV) (1)

Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered (1)

Rx; REMS program required (excessive sedation/loss of consciousness during infusion) (1)

Showing below up to 1 result in range #1 to #1.

B

Brexanolone

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