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Drilldown: Medicines

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Medicines (732)

Medicines > generic

: Codeine

or Sodium Oxybate

& classes: GABAB Agonist; Endogenous GHB receptor agonist

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Xyrem; Xywav (lower-sodium formulation with Ca/Mg/K salts) (1)

Agonist at the metabotropic GABAB receptor and the endogenous γ-hydroxybutyrate (GHB) receptor. Produces deep sleep with increased slow-wave architecture, suppression of REM intrusion, and cataplexy reduction. (1)

'"`UNIQ--vote-00000717-QINU`"', '"`UNIQ--vote-00000718-QINU`"', '"`UNIQ--vote-00000719-QINU`"' (1)

2.25 g at bedtime + 2.25 g 2.5–4 h later; titrate weekly to 6–9 g/night total (1)

0.5 g/mL oral solution (1)

9 g/night (1)

Oral (must be taken in bed; effects within minutes) (1)

15–30 min (fasting) (1)

~3 h per dose (twice-nightly schedule required) (1)

30–60 min (1)

~25% (high first-pass) (1)

Schedule III; REMS-restricted (Schedule I if outside the pharmaceutical channel, same molecule as illicit GHB) (1)

Showing below up to 1 result in range #1 to #1.

S

Sodium Oxybate

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