Drilldown: Medicines - Pharmacopedia

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Medicines (732)

Medicines > generic: None

& classes: Neuroactive steroid

& duration: 14-day course; effect persists after discontinuation in trials

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Zurzuvae (1)

Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)

Postpartum depression (PPD) in adults (FDA-approved 2023) (1)

50 mg PO once daily with fatty food in the evening × 14 days (1)

20 mg, 25 mg, 30 mg capsules (1)

50 mg/d × 14 d (1)

Oral (1)

Day 3 of dosing in trials; sustained through day 45 (1)

~16-23 hours (1)

Adequate (food-dependent, must take with fatty meal) (1)

Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1)

Rx, Schedule IV (US) (1)

Showing below up to 1 result in range #1 to #1.

Z

Zuranolone

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