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Medicines > classes: Neuroactive steroid & fda max : No fixed maximum; titrated to TSH target or Single 60-hour course

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generic:
None (1)
brand:
Zulresso (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
Postpartum depression (PPD) in adults (1)
starting dose:
Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h (1)
preparations:
100 mg/20 mL vial, single-use (1)
fda max: (Click arrow to add another value)
routes:
Intravenous (continuous infusion in a REMS-certified facility) (1)
onset:
Antidepressant effect within hours of infusion start; sustained at 30 days (1)
duration:
Single infusion course (1)
halflife:
~9 hours (terminal) (1)
bioavailability:
100% (IV) (1)
pregnancy:
Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered (1)
legal:
Rx; REMS program required (excessive sedation/loss of consciousness during infusion) (1)

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