Drilldown/Medicines

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Medicines (732)

Medicines > generic

: Polyethylene glycol 3350 with electrolytes

or None

& classes: Neuroactive steroid

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Zulresso (1) · Zurzuvae (1)

None (1) · Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)

Postpartum depression (PPD) in adults (1) · Postpartum depression (PPD) in adults (FDA-approved 2023) (1)

50 mg PO once daily with fatty food in the evening × 14 days (1) · Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h (1)

100 mg/20 mL vial, single-use (1) · 20 mg, 25 mg, 30 mg capsules (1)

50 mg/d × 14 d (1) · Single 60-hour course (1)

Intravenous (continuous infusion in a REMS-certified facility) (1) · Oral (1)

Antidepressant effect within hours of infusion start; sustained at 30 days (1) · Day 3 of dosing in trials; sustained through day 45 (1)

14-day course; effect persists after discontinuation in trials (1) · Single infusion course (1)

~16-23 hours (1) · ~9 hours (terminal) (1)

100% (IV) (1) · Adequate (food-dependent, must take with fatty meal) (1)

Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1) · Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered (1)

Rx, Schedule IV (US) (1) · Rx; REMS program required (excessive sedation/loss of consciousness during infusion) (1)

Showing below up to 2 results in range #1 to #2.

B

Brexanolone

Z

Zuranolone

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