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Medicines > classes: Norepinephrine-dopamine reuptake inhibitor (NDRI) & halflife : ~12 hours or ~7.1 hours

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generic:
None (1)
brand:
Sunosi (1)
classes: (Click arrow to add another value)
mechanism:
Selective dopamine and norepinephrine reuptake inhibitor (DAT and NET inhibition). Unlike amphetamine, does not significantly release monoamines, pure reuptake inhibition. (1)
uses:
Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1)
starting dose:
Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1)
preparations:
75 mg, 150 mg tablets (1)
fda max:
150 mg/d (1)
routes:
Oral (1)
onset:
~30-60 min (1)
duration:
~9 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~95% (1)
pregnancy:
Limited data; pregnancy exposure registry available (1)
legal:
Rx, Schedule IV (US) (1)

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