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Medicines > classes: PDE5 Inhibitor & onset : 30–60 min or ~30 min

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generic:
Sildenafil (1) · Vardenafil (1)
brand:
Levitra, Staxyn (1) · Viagra, Revatio (1)
classes: (Click arrow to add another value)
mechanism:
Selective inhibitor of PDE5. Slightly higher PDE5/PDE6 selectivity vs sildenafil (less visual side effect) but more PDE1 cross-activity (occasional QT effects at high doses). (1) · Selective inhibitor of phosphodiesterase type 5 (PDE5), preventing cGMP breakdown in vascular smooth muscle. In the corpus cavernosum, potentiates the NO/cGMP cascade triggered by sexual stimulation. (1)
uses:
'"`UNIQ--vote-00000669-QINU`"' (1) · '"`UNIQ--vote-00000705-QINU`"', '"`UNIQ--vote-00000706-QINU`"' (1)
starting dose:
10 mg ~1 h before sexual activity (1) · 50 mg ~1 h before sexual activity (ED); 20 mg TID (PAH) (1)
preparations:
2.5, 5, 10, 20 mg tabs (Levitra); 10 mg ODT (Staxyn) (1) · 25, 50, 100 mg tabs (Viagra); 20 mg tabs and 10 mg/mL oral suspension (Revatio) (1)
fda max:
100 mg/d (ED); 20 mg TID (PAH) (1) · 20 mg/d (1)
routes:
IV (Revatio) (1) · Oral (2)
onset: (Click arrow to add another value)
duration:
4–5 h (1) · ~4 h (1)
halflife:
4–5 h (1) · ~4 h (1)
bioavailability:
~15% (extensive hepatic first-pass) (1) · ~40% (1)
pregnancy:
Category B (2)
legal:
Rx-only in US (2)

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