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Medicines > classes: PDE5 Inhibitor & onset : 30 min or ~30 min

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generic:
Tadalafil (1) · Vardenafil (1)
brand:
Cialis, Adcirca (1) · Levitra, Staxyn (1)
classes: (Click arrow to add another value)
mechanism:
Selective inhibitor of PDE5 with a substantially longer half-life than other PDE5 inhibitors, allowing once-daily continuous dosing. (1) · Selective inhibitor of PDE5. Slightly higher PDE5/PDE6 selectivity vs sildenafil (less visual side effect) but more PDE1 cross-activity (occasional QT effects at high doses). (1)
uses:
'"`UNIQ--vote-00000669-QINU`"' (1) · '"`UNIQ--vote-00000738-QINU`"', '"`UNIQ--vote-00000739-QINU`"', '"`UNIQ--vote-0000073A-QINU`"' (1)
starting dose:
10 mg PRN; 2.5–5 mg daily for continuous coverage / BPH (1) · 10 mg ~1 h before sexual activity (1)
preparations:
2.5, 5, 10, 20 mg tabs (1) · 2.5, 5, 10, 20 mg tabs (Levitra); 10 mg ODT (Staxyn) (1)
fda max:
20 mg/d (1) · 20 mg/d (ED, PRN); 5 mg/d (daily / BPH); 40 mg/d (PAH) (1)
routes:
Oral (2)
onset: (Click arrow to add another value)
duration:
4–5 h (1) · Up to 36 h ("the weekend pill") (1)
halflife:
4–5 h (1) · ~17.5 h (1)
bioavailability:
Reasonable (not formally established as a percentage) (1) · ~15% (extensive hepatic first-pass) (1)
pregnancy:
Category B (2)
legal:
Rx-only in US (2)

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