Jump to content

Drilldown: Medicines

Choose a table:


Medicines > generic: None & classes: Selective 5HT2A inverse agonist (with weaker 5HT2C inverse agonism) & onset: Benefit over weeks of dosing

Use the filters below to narrow your results.

generic: (Click arrow to add another value)
brand:
Nuplazid (1)
classes: (Click arrow to add another value)
mechanism:
Selective inverse agonist at 5HT2A receptors with weaker activity at 5HT2C. Has no significant dopamine D2 affinity, unique among approved antipsychotics. Inverse agonism (rather than antagonism) reduces constitutive 5HT2A receptor activity below baseline. (1)
uses:
Hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Investigational for psychosis in other dementias and as augmentation for depression. (1)
starting dose:
34 mg PO once daily (1)
preparations:
10 mg, 34 mg capsules/tablets (1)
fda max:
34 mg/d (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
Daily dosing (1)
halflife:
~57 hours (parent), ~200 h (active metabolite) (1)
bioavailability:
Not characterized; oral dosing once daily (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx. FDA black-box warning for increased mortality in elderly patients with dementia-related psychosis (class warning shared with all antipsychotics) (1)

Showing below up to 1 result in range #1 to #1.

View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)


View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"