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Drilldown: Medicines

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Medicines > classes: None & duration : 12 hours or None

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generic:
Anadenanthera colubrina (1) · Anadenanthera peregrina (1) · Dextromethorphan / Quinidine (1) · ketamine (1) · lithium (1) · mescaline (1) · opium (1) · Psychotria viridis (1)
brand:
None (4) · ketalar (1) · Laudanum, Dropizol (1) · Lithobid (1) · Nuedexta (1)
classes: (Click arrow to add another value)
mechanism:
5HT1a (1) · NMDA-receptor antagonism (1) · Source of DMT-class tryptamines (1) · Source of [[DMT]], bufotenine, and 5-MeO-DMT (1) · Source of [[DMT|N,N-dimethyltryptamine]] (1) · TBD (1) · '"`UNIQ--vote-00001580-QINU`"' First FDA-approved treatment for PBA. The 10 mg quinidine daily dose is far below antiarrhythmic levels but sufficient to nearly fully inhibit CYP2D6, the basis of the combination's pharmacokinetic rationale'"`UNIQ--ref-00001581-QINU`"'. (1) · µ-opioid agonism (1)
uses:
None (5) · Antimanic, Antidepressive, Antisuicide (1) · Pain, cough, disquiet (1) · '"`UNIQ--vote-00001582-QINU`"' (1)
starting dose:
None (7) · 1 capsule (20/10 mg dextromethorphan/quinidine) PO once daily × 7 days, then 1 capsule BID (1)
preparations:
None (7) · 20 mg dextromethorphan HBr / 10 mg quinidine sulfate capsules (1)
fda max:
None (7) · 1 capsule BID (40 mg DXM / 20 mg quinidine per day) (1)
routes:
None (7) · Oral (1)
onset:
None (7) · PBA episode reduction within 1-2 weeks (1)
duration: (Click arrow to add another value)
halflife:
None (7) · Dextromethorphan substantially prolonged by quinidine's CYP2D6 inhibition (typical extensive metabolizers see ~10× higher AUC); quinidine ~6-8 hours'"`UNIQ--ref-00001583-QINU`"' (1)
bioavailability:
None (7) · Increased substantially via CYP2D6 inhibition'"`UNIQ--ref-00001584-QINU`"' (1)
pregnancy:
None (7) · Limited data; quinidine has been used in pregnancy as antiarrhythmic.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (7) · [[USLegal:Prescription only|Rx-only]] in US. Caution with QT-prolonging medicines (quinidine itself is class IA antiarrhythmic, and the dose here, though sub-antiarrhythmic, still contributes to QT)'"`UNIQ--ref-00001585-QINU`"' (1)

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