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Medicines > classes: atypical)]] & onset : Modest appetite suppression within weeks; weight loss over months or Over weeks

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generic:
Bupropion / Naltrexone (1)
brand:
Contrave (US), Mysimba (EU) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00001567-QINU`"' (1)
starting dose:
Week 1: 1 tablet (8/90 mg) PO morning; week 2: 1 tablet AM + 1 PM; week 3: 2 AM + 1 PM; week 4 onward: 2 AM + 2 PM (32 mg naltrexone / 360 mg bupropion/d) (1)
preparations:
8 mg naltrexone / 90 mg bupropion ER tablets (titration-pack design) (1)
fda max:
32 mg naltrexone / 360 mg bupropion per day (1)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12 hours (BID dosing required) (1)
halflife:
Naltrexone ~4 hours (6β-naltrexol metabolite ~13 hours); bupropion ~21 hours'"`UNIQ--ref-00001568-QINU`"' (1)
bioavailability:
Naltrexone ~5% (oral, extensive first-pass to 6β-naltrexol); bupropion ER ~87%'"`UNIQ--ref-00001569-QINU`"' (1)
pregnancy:
Contraindicated in pregnancy (FDA label).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1)

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