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Medicines > generic: Indomethacin & classes: potent non-selective)]] & routes: intravenous (PDA closure only)

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generic: (Click arrow to add another value)
brand:
Indocin (oral, IV, suppository), Tivorbex (low-dose), Indo-Lemmon (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"', '"`UNIQ--vote-00000022-QINU`"', '"`UNIQ--vote-00000023-QINU`"', '"`UNIQ--vote-00000024-QINU`"', '"`UNIQ--vote-00000025-QINU`"' (1)
starting dose:
Acute gout: 50 mg PO TID until symptom relief, then taper; maximum 200 mg/day for 3-5 days. Rheumatoid arthritis / osteoarthritis: 25-50 mg PO BID-TID. Patent ductus arteriosus: 0.2 mg/kg IV, then 0.1-0.2 mg/kg every 12-24 hours for 2 doses (1)
preparations:
Capsules 25, 50 mg; ER capsules 75 mg; oral suspension 25 mg/5 mL; suppositories 50 mg; injection 1 mg/vial (PDA closure) (1)
fda max:
200 mg/day (typical adult oral) (1)
routes: (Click arrow to add another value)
onset:
30-60 minutes (oral); rapid relief in acute gout (1)
duration:
4-6 hours (IR); 24 hours (ER) (1)
halflife:
4-5 hours'"`UNIQ--ref-00000026-QINU`"' (1)
bioavailability:
~100% (oral)'"`UNIQ--ref-00000027-QINU`"' (1)
pregnancy:
Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning; contraindicated from 30 weeks (risk of premature ductus arteriosus closure, which is paradoxically the basis of the neonatal PDA-closure indication)'"`UNIQ--ref-00000028-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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