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Drilldown: Medicines

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Medicines (732)

Medicines > generic: Nortriptyline (hydrochloride)

& classes: secondary amine)]]

& duration: 24 hours (HS dosing)

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Pamelor (US brand discontinued; generic widely available), Aventyl (1)

'"`UNIQ--vote-00000019-QINU`"' Therapeutic plasma-level monitoring is standard practice for TCAs given the narrow therapeutic index and the established plasma-level-efficacy correlation. CYP2D6 substrate; CPIC PGx guidance applies for dose individualization'"`UNIQ--ref-0000001A-QINU`"'. (1)

'"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"', '"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"' (1)

Depression: 25 mg PO TID-QID or 75 mg at bedtime, titrate to 75-150 mg/day. Neuropathic pain: 10-25 mg at bedtime, titrate to 50-100 mg/day. Elderly: 10 mg at bedtime (Beers-list cautions, though less than amitriptyline) (1)

Capsules 10, 25, 50, 75 mg; oral solution 10 mg/5 mL (1)

150 mg/day; therapeutic plasma-level monitoring recommended (target 50-150 ng/mL window) (1)

Oral (1)

Pain and migraine prophylaxis effect 1-4 weeks; antidepressant effect 4-6 weeks (1)

18-44 hours'"`UNIQ--ref-00000020-QINU`"' (1)

~50% (oral)'"`UNIQ--ref-00000021-QINU`"' (1)

TCA class signal; limited human data specific to nortriptyline.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-00000022-QINU`"' (1)

Showing below up to 1 result in range #1 to #1.

N

Nortriptyline

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