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Drilldown: Medicines

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Medicines > classes: the first approved & duration : Biologic 12-36 hours (intermediate-acting) or ~7-8 hours

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generic:
None (1)
brand:
Belsomra (1)
classes: (Click arrow to add another value)
mechanism:
Competitive antagonist at OX1R and OX2R. First-in-class DORA. Receptor dissociation slower than lemborexant or daridorexant. (1)
uses:
Insomnia (sleep onset and/or maintenance) in adults (FDA-approved August 2014). Also studied for insomnia in mild-moderate Alzheimer disease. (1)
starting dose:
10 mg PO 30 min before bedtime (with ≥7 hours of sleep planned) (1)
preparations:
5 mg, 10 mg, 15 mg, 20 mg tablets (1)
fda max:
20 mg/d (1)
routes:
Oral (1)
onset:
~30 min (1)
duration: (Click arrow to add another value)
halflife:
~12 hours (1)
bioavailability:
~82% (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx, Schedule IV (US) (1)

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