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Drilldown: Medicines

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Medicines (732)

Medicines > generic

: Polyethylene glycol 3350 with electrolytes

or None

& classes: wake-promoting agent

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Sunosi (1) · Wakix (1)

None (1) · Selective dopamine and norepinephrine reuptake inhibitor (DAT and NET inhibition). Unlike amphetamine, does not significantly release monoamines, pure reuptake inhibition. (1)

Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1) · Excessive daytime sleepiness or cataplexy in adults with narcolepsy (FDA-approved August 2019) (1)

Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1) · Week 1: 8.9 mg PO once daily in the morning. Week 2: 17.8 mg. Week 3+: 35.6 mg (max). Titrate as needed. (1)

4.45 mg, 17.8 mg tablets (1) · 75 mg, 150 mg tablets (1)

150 mg/d (1) · 35.6 mg/d (1)

Oral (2)

Wake-promoting effect over weeks of titration (1) · ~30-60 min (1)

Daily morning dosing (1) · ~9 hours (1)

~20 hours (1) · ~7.1 hours (1)

Not formally established; oral once-daily adequate (1) · ~95% (1)

Limited data; pitolisant may reduce hormonal contraceptive efficacy (1) · Limited data; pregnancy exposure registry available (1)

Rx, '''not a controlled substance''' (unique among wake-promoting agents) (1) · Rx, Schedule IV (US) (1)

Showing below up to 2 results in range #1 to #2.

P

Pitolisant

S

Solriamfetol

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