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Drilldown: Medicines

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Medicines > classes: with mineralocorticoid activity)]] & onset : Hours or Slowing of cognitive decline over 18 months (modest effect, ~27% relative slowing)

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generic:
Hydrocortisone (cortisol) (1)
brand:
Cortef (oral), Solu-Cortef (IV), many topical brands (Cortizone, OTC); Plenadren, Alkindi (modified-release for adrenal insufficiency) (1)
classes: (Click arrow to add another value)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000ACD-QINU`"', '"`UNIQ--vote-00000ACE-QINU`"', '"`UNIQ--vote-00000ACF-QINU`"', '"`UNIQ--vote-00000AD0-QINU`"' (1)
starting dose:
Physiologic replacement 15-25 mg/d divided (e.g., 10 mg AM, 5 mg noon, 5 mg afternoon); stress dose 50-100 mg IV q6-8h; adrenal crisis 100 mg IV then 50-100 mg q6h; topical 0.5-2.5% applied 2-4×/d (1)
preparations:
5, 10, 20 mg oral tablets; 100, 250, 500, 1000 mg IV (Solu-Cortef); 0.5%, 1%, 2.5% topical creams/ointments; rectal foam and enemas (1)
fda max:
Indication-specific (1)
routes:
IM (1) · IV (1) · Oral (1) · rectal (1) · topical (1)
onset: (Click arrow to add another value)
duration:
Biologic ~8-12 hours (short-acting) (1)
halflife:
Plasma ~1-2 hours; biologic ~8-12 hours'"`UNIQ--ref-00000AD1-QINU`"' (1)
bioavailability:
~96% (oral)'"`UNIQ--ref-00000AD2-QINU`"' (1)
pregnancy:
Use when benefits outweigh; widely used at physiologic doses for adrenal insufficiency.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC (low-dose topicals) and [[USLegal:Prescription only|Rx-only]] (other forms) in US (1)

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