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Medicines > fda max: 50 mg/day (no efficacy benefit shown for higher doses despite the 100 mg strength being available) & duration : 24 hours or Roughly 20-25% of an IV bolus remains intravascular at 1 hour

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generic:
Desvenlafaxine (succinate) (1)
brand:
Pristiq (1)
classes:
[[:Category:Antidepressants|Antidepressant]] (1) · [[:Category:SNRIs|Serotonin-norepinephrine reuptake inhibitor (SNRI)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000017-QINU`"', '"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"' (1)
starting dose:
50 mg PO once daily ('''no titration required''', distinguishing it favorably from venlafaxine) (1)
preparations:
ER tablets 25, 50, 100 mg (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Antidepressant effect emerges over 1-2 weeks (1)
duration: (Click arrow to add another value)
halflife:
~11 hours'"`UNIQ--ref-0000001A-QINU`"' (1)
bioavailability:
~80% (oral)'"`UNIQ--ref-0000001B-QINU`"' (1)
pregnancy:
Observational signal for neonatal adaptation syndrome with late-pregnancy exposure (SNRI class effect).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the antidepressant '''Boxed Warning''' for suicidality in children, adolescents, and young adults'"`UNIQ--ref-0000001C-QINU`"' (1)

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