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Medicines > routes: IV (with caution) & duration : 4-6 hours or IR 4–6 h; XR 10–12 h; Mydayis 14–16 h

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generic:
Promethazine (hydrochloride) (1)
brand:
Phenergan, Promethegan (suppositories) (1)
classes:
[[:Category:Antiemetics|Antiemetic]] (1) · [[:Category:Antihistamines|First-generation antihistamine]] (1) · [[:Category:Phenothiazines|Phenothiazine]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000001D-QINU`"', '"`UNIQ--vote-0000001E-QINU`"', '"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"' (1)
starting dose:
Allergy: 25 mg PO BID-QID. Nausea/vomiting: 12.5-25 mg PO/IM/IV/PR every 4-6 hours. Motion sickness: 25 mg PO 30-60 minutes before travel. '''Pediatric <2 years: contraindicated''' (1)
preparations:
Tablets 12.5, 25, 50 mg; oral syrup 6.25 mg/5 mL; suppositories 12.5, 25, 50 mg; injection 25 mg/mL and 50 mg/mL (1)
fda max:
100 mg/day (adult) (1)
routes: (Click arrow to add another value)
onset:
20 minutes (oral); 5 minutes (IV) (1)
duration: (Click arrow to add another value)
halflife:
12-15 hours'"`UNIQ--ref-00000022-QINU`"' (1)
bioavailability:
~25% (oral, with extensive first-pass)'"`UNIQ--ref-00000023-QINU`"' (1)
pregnancy:
Older agent with substantial use experience, including in hyperemesis gravidarum; broadly reassuring observational data'"`UNIQ--ref-00000024-QINU`"' (1)
legal:
None (1)

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