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Medicines > fda max: Indication-specific; HE may require high-volume dosing & duration : 4-6 hours (IR); 24 hours (ER) or Hours

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generic:
Lactulose (1)
brand:
Kristalose, Constulose, Generlac, Enulose (1)
classes:
[[:Category:Disaccharides|Non-absorbable disaccharide]] (1) · [[:Category:Hepatic_encephalopathy_treatments|Hepatic encephalopathy treatment]] (1) · [[:Category:Osmotic_laxatives|Osmotic laxative]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000F5C-QINU`"', '"`UNIQ--vote-00000F5D-QINU`"' (1)
starting dose:
Constipation: 15-30 mL PO daily (titrate to 1-2 soft stools/day); hepatic encephalopathy: 20-30 g (30-45 mL) PO/PR every 1-2 hours acutely until soft stools, then BID-QID to target 2-3 soft stools/day (1)
preparations:
10 g/15 mL solution (Constulose); 10 g, 20 g powder packets (Kristalose) (1)
fda max: (Click arrow to add another value)
routes:
especially in acute HE) (1) · Oral (1) · rectal (enema (1)
onset:
Constipation: 24-48 hours; HE: ammonia reduction within hours of stool production (1)
duration: (Click arrow to add another value)
halflife:
Not meaningfully described — lactulose is not significantly absorbed (1)
bioavailability:
<3% systemic absorption (the basis of the safety and mechanism)'"`UNIQ--ref-00000F5E-QINU`"' (1)
pregnancy:
Generally considered safe (minimal systemic absorption).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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