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Medicines > fda max: 2 tablets/day (dextromethorphan 90 mg / bupropion 210 mg) & duration : 4-6 hours (IR); 24 hours (ER) or Sustained with twice-daily dosing

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generic:
None (1)
brand:
Auvelity (dextromethorphan/bupropion ER) (1)
classes:
NMDA receptor antagonist + sigma-1 agonist + NDRI (combination) (1)
mechanism:
None (1)
uses:
Major depressive disorder in adults (FDA-approved August 2022) (1)
starting dose:
1 tablet (dextromethorphan 45 mg / bupropion 105 mg) PO daily × 3 days, then increase to 1 tablet BID (1)
preparations:
Dextromethorphan 45 mg + bupropion 105 mg ER tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Significant antidepressant response by week 1 in trials (faster than monoaminergic antidepressants which take 4-6 weeks) (1)
duration: (Click arrow to add another value)
halflife:
Dextromethorphan ~22 h (when CYP2D6 inhibited); bupropion ~21 h (1)
bioavailability:
Not formally characterized for the combination (1)
pregnancy:
Limited data; avoid (1)
legal:
Rx (1)

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