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Drilldown: Medicines

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Medicines > routes: topical & duration : 8-12 hours or None

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generic:
Atropa belladonna (1) · Metronidazole (1)
brand:
Deadly nightshade (1) · Flagyl, Metrocream, Metrogel, Metrogel-Vaginal, Noritate (1)
classes:
Daimonica (1) · Plant Medicine (1) · Tropane alkaloid plant (1) · [[:Category:Antibacterials|Antibacterial (anaerobic)]] (1) · [[:Category:Antiprotozoals|Antiprotozoal]] (1) · [[:Category:Nitroimidazoles|Nitroimidazole antibiotic]] (1)
mechanism:
None (1) · Tropane alkaloids: hyoscyamine (dominant; the racemic form is atropine), scopolamine. Competitive muscarinic antagonism. (1)
uses:
'"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (1) · '"`UNIQ--vote-00000BE3-QINU`"', '"`UNIQ--vote-00000BE4-QINU`"', '"`UNIQ--vote-00000BE5-QINU`"', '"`UNIQ--vote-00000BE6-QINU`"', '"`UNIQ--vote-00000BE7-QINU`"', '"`UNIQ--vote-00000BE8-QINU`"', '"`UNIQ--vote-00000BE9-QINU`"', '"`UNIQ--vote-00000BEA-QINU`"' (1)
starting dose:
None (1) · 500 mg PO TID × 7-10 days (most indications); 2 g single dose for trichomoniasis; 500 mg IV q8h for severe anaerobic infection; rectal 1 g BID (1)
preparations:
250, 500 mg tablets; 750 mg ER; 500 mg/100 mL IV; 0.75-1% topical gel/cream; 0.75% vaginal gel; suppository (1) · Leaves, berries, root. Historically: belladonna cigarettes ("Asthmador") OTC in US until the 1970s (1)
fda max:
None (1) · ~4 g/d (severe systemic infection) (1)
routes: (Click arrow to add another value)
onset:
None (1) · Hours (1)
duration: (Click arrow to add another value)
halflife:
None (1) · 6-8 hours'"`UNIQ--ref-00000BEB-QINU`"' (1)
bioavailability:
None (1) · ~80% (oral)'"`UNIQ--ref-00000BEC-QINU`"' (1)
pregnancy:
None (1) · Generally considered safe after the first trimester; first-trimester use weighed against indication.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Plant unrestricted; pharmaceutical atropine Rx-only (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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