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Medicines > fda max: 30 mg/d for short-term use & duration : Hours or Route- and formulation-dependent

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generic:
Bisacodyl (1)
brand:
Dulcolax, Correctol, Bisac-Evac (1)
classes:
[[:Category:Diphenylmethane_laxatives|Diphenylmethane laxative]] (1) · [[:Category:Stimulant_laxatives|Stimulant laxative]] (1)
mechanism:
'"`UNIQ--vote-00001067-QINU`"' Chronic use is associated with cathartic colon (colonic dilation, loss of haustration), hypokalemia, and laxative dependence; reserved for short-term use or bowel prep with breaks between courses'"`UNIQ--ref-00001068-QINU`"'. (1)
uses:
'"`UNIQ--vote-00001069-QINU`"', '"`UNIQ--vote-0000106A-QINU`"' (1)
starting dose:
5-15 mg PO once at bedtime; 10 mg PR for faster effect; bowel prep regimens use higher single doses (1)
preparations:
5 mg enteric-coated tablets; 10 mg rectal suppositories; OTC and Rx (1)
fda max: (Click arrow to add another value)
routes:
Oral (1) · rectal (1)
onset:
PO 6-12 hours; PR 15-60 minutes (1)
duration: (Click arrow to add another value)
halflife:
Variable; effect dependent on local intestinal action rather than systemic kinetics'"`UNIQ--ref-0000106B-QINU`"' (1)
bioavailability:
Low systemic absorption (enteric coating delivers drug to colon)'"`UNIQ--ref-0000106C-QINU`"' (1)
pregnancy:
Generally considered acceptable for short-term use.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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