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Medicines > fda max: 4% topical; limit duration of use & duration : Hours per application or ~9 hours

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generic:
Hydroquinone (1)
brand:
Lustra, EpiQuin Micro, Melquin, Tri-Luma (with tretinoin and fluocinolone) (1)
classes:
[[:Category:Depigmenting_agents|Depigmenting agent]] (1) · [[:Category:Skin_lightening_agents|Skin-lightening agent]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00001215-QINU`"', '"`UNIQ--vote-00001216-QINU`"', '"`UNIQ--vote-00001217-QINU`"' (1)
starting dose:
Apply thin layer to hyperpigmented areas BID; limit to 4-6 month courses to avoid ochronosis (1)
preparations:
4% prescription cream/lotion; OTC 2% withdrawn in US (2020 CARES Act); compounded higher strengths available (1)
fda max: (Click arrow to add another value)
routes:
Topical (1)
onset:
Visible lightening at 4-12 weeks (1)
duration: (Click arrow to add another value)
halflife:
Not meaningfully described — topical local action with minimal systemic absorption'"`UNIQ--ref-00001218-QINU`"' (1)
bioavailability:
Topical with limited but measurable systemic absorption'"`UNIQ--ref-00001219-QINU`"' (1)
pregnancy:
Generally avoided in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US since 2020 (OTC 2% formulations withdrawn under CARES Act due to safety concerns) (1)

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