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Drilldown: Medicines

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Medicines > routes: oral & duration : N/A or ~9 hours

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generic:
None (1) · Riboflavin (vitamin B2) (1)
brand:
Many generics/OTC (1) · Sunosi (1)
classes:
Norepinephrine-dopamine reuptake inhibitor (NDRI) (1) · wake-promoting agent (1) · [[:Category:B-vitamins|B-vitamin]] (1) · [[:Category:Vitamins|Vitamin]] (1)
mechanism:
Selective dopamine and norepinephrine reuptake inhibitor (DAT and NET inhibition). Unlike amphetamine, does not significantly release monoamines, pure reuptake inhibition. (1) · '"`UNIQ--vote-0000124C-QINU`"' The 400 mg/d dose for migraine prophylaxis is supported by randomized trials (Schoenen 1998) and remains a low-risk evidence-based supplement option. Characteristic bright-yellow urine fluorescence with high-dose oral supplementation. (1)
uses:
Excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA) (1) · '"`UNIQ--vote-0000124D-QINU`"', '"`UNIQ--vote-0000124E-QINU`"', '"`UNIQ--vote-0000124F-QINU`"' (1)
starting dose:
Migraine prophylaxis: 400 mg PO daily; deficiency replacement 5-30 mg/d (1) · Narcolepsy: 75 mg PO once daily upon awakening, titrate every 3 days. OSA: 37.5 mg PO once daily, titrate. (1)
preparations:
25, 50, 100, 250, 400 mg tablets; OTC (1) · 75 mg, 150 mg tablets (1)
fda max:
150 mg/d (1) · No strict ceiling for water-soluble vitamin; UL not set (1)
routes: (Click arrow to add another value)
onset:
Migraine effect after 1-3 months of daily use (1) · ~30-60 min (1)
duration: (Click arrow to add another value)
halflife:
~1-2 hours plasma (riboflavin itself); FAD/FMN tissue cofactors are continuous (1) · ~7.1 hours (1)
bioavailability:
~50-60% (oral; food enhances) (1) · ~95% (1)
pregnancy:
Limited data; pregnancy exposure registry available (1) · Safe at replacement and supplement doses.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1) · Rx, Schedule IV (US) (1)

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