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Drilldown: Medicines

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Medicines > duration: 12 hours & pregnancy : Limited data; avoid or None

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generic:
Apixaban (1) · Doxycycline (1)
brand:
Eliquis (1) · Vibramycin, Doryx, Oracea, Adoxa, Monodox, Acticlate (1)
classes:
[[:Category:Anticoagulants|Anticoagulant]] (1) · [[:Category:Bacteriostatic_antibiotics|Bacteriostatic antibiotic]] (1) · [[:Category:Direct_factor_Xa_inhibitors|Direct factor Xa inhibitor]] (1) · [[:Category:DOACs|Direct oral anticoagulant (DOAC)]] (1) · [[:Category:Tetracycline_antibiotics|Tetracycline antibiotic]] (1)
mechanism:
None (1) · '"`UNIQ--vote-000001F6-QINU`"' CYP3A4 (primary) and P-glycoprotein substrate; strong dual inhibitors or inducers materially shift exposure. Reversal: andexanet alfa for life-threatening bleeding; 4F-PCC commonly used off-label when andexanet unavailable'"`UNIQ--ref-000001F7-QINU`"'. (1)
uses:
'"`UNIQ--vote-000001F8-QINU`"', '"`UNIQ--vote-000001F9-QINU`"', '"`UNIQ--vote-000001FA-QINU`"' (1) · '"`UNIQ--vote-00000475-QINU`"', '"`UNIQ--vote-00000476-QINU`"', '"`UNIQ--vote-00000477-QINU`"', '"`UNIQ--vote-00000478-QINU`"', '"`UNIQ--vote-00000479-QINU`"', '"`UNIQ--vote-0000047A-QINU`"', '"`UNIQ--vote-0000047B-QINU`"', '"`UNIQ--vote-0000047C-QINU`"' (1)
starting dose:
100 mg PO BID; rickettsial 200 mg/d; doxy-PEP 200 mg within 72 hours after condomless sex (1) · NVAF: 5 mg PO BID (2.5 mg BID if 2 of 3: age ≥80, weight ≤60 kg, serum creatinine ≥1.5 mg/dL); acute VTE: 10 mg BID for 7 days, then 5 mg BID (1)
preparations:
2.5 mg, 5 mg tablets (1) · 50 mg, 75 mg, 100 mg, 150 mg tablets and capsules; delayed-release; suspension; IV (1)
fda max:
10 mg BID for the first 7 days of acute VTE; otherwise 5 mg BID (1) · ~200 mg/d for most indications; higher doses for severe infections (1)
routes:
IV (1) · Oral (2)
onset:
Hours (1) · Peak anticoagulant effect 3-4 hours (1)
duration: (Click arrow to add another value)
halflife:
16-22 hours'"`UNIQ--ref-0000047D-QINU`"' (1) · ~12 hours'"`UNIQ--ref-000001FB-QINU`"' (1)
bioavailability:
~50% (oral; not significantly affected by food)'"`UNIQ--ref-000001FC-QINU`"' (1) · ~95% (oral; reduced by dairy, antacids, iron via divalent-cation chelation, though less than for tetracycline itself)'"`UNIQ--ref-0000047E-QINU`"' (1)
pregnancy: (Click arrow to add another value)
legal:
[[USLegal:Prescription only|Rx-only]] in US (2)

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