Drilldown: Medicines

None · Codeine · 1,4-Butanediol · 1B-LSD · 1cP-LSD · 1P-LSD · 1V-LSD · 2-AI · 2-FA · 2-FDCK · 2-FMA · 25B-NBOH · 25B-NBOMe · 25C-NBOH · 25C-NBOMe · 25I-NBOH · 25I-NBOMe · 25N-NBOMe · 2C-B · 2C-B-FLY

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Zurzuvae (1)

GABA-A positive allosteric modulator (oral) (1) · Neuroactive steroid (1)

Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)

Postpartum depression (PPD) in adults (FDA-approved 2023) (1)

50 mg PO once daily with fatty food in the evening × 14 days (1)

20 mg, 25 mg, 30 mg capsules (1)

50 mg/d × 14 d (1)

Oral (1)

Day 3 of dosing in trials; sustained through day 45 (1)

None · 24 hours · 4-6 hours · 12 hours · 6-8 hours · Daily dosing · 8-12 hours · 12-24 hours · Hours · Hours per application · 24 hours (HS dosing) · 24 hours (once-daily dosing) · 24 h · N/A · N/A (replacement) · Variable · ~7-8 hours · 3-5 hours · 4-6 hours (IR); 24 hours (ER) · 6-12 hours

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~16-23 hours (1)

Adequate (food-dependent, must take with fatty meal) (1)

Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1)

Rx, Schedule IV (US) (1)