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Drilldown: Medicines

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Medicines > generic: None & duration: 14-day course; effect persists after discontinuation in trials

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generic: (Click arrow to add another value)
brand:
Zurzuvae (1)
classes:
GABA-A positive allosteric modulator (oral) (1) · Neuroactive steroid (1)
mechanism:
Synthetic neuroactive steroid (an analog of allopregnanolone), bioavailable orally unlike brexanolone. Positive allosteric modulator at GABA-A receptors including extrasynaptic δ-containing subtypes. (1)
uses:
Postpartum depression (PPD) in adults (FDA-approved 2023) (1)
starting dose:
50 mg PO once daily with fatty food in the evening × 14 days (1)
preparations:
20 mg, 25 mg, 30 mg capsules (1)
fda max:
50 mg/d × 14 d (1)
routes:
Oral (1)
onset:
Day 3 of dosing in trials; sustained through day 45 (1)
duration: (Click arrow to add another value)
halflife:
~16-23 hours (1)
bioavailability:
Adequate (food-dependent, must take with fatty meal) (1)
pregnancy:
Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1)
legal:
Rx, Schedule IV (US) (1)

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