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Drilldown: Medicines

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Medicines > routes: Oral & duration: 24 h & halflife: ~10 h (CYP2D6 extensive metabolizers); up to 31 h (poor metabolizers)

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generic:
Nebivolol (1)
brand:
Bystolic (1)
classes:
Beta Blocker (1) · Cardioselective (β1) + vasodilator (1)
mechanism:
The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. (1)
uses:
'"`UNIQ--vote-0000059D-QINU`"' (1)
starting dose:
5 mg daily (1)
preparations:
2.5, 5, 10, 20 mg tabs (1)
fda max:
40 mg/d (1)
routes: (Click arrow to add another value)
onset:
1–2 h (1)
duration: (Click arrow to add another value)
halflife: (Click arrow to add another value)
bioavailability:
~12% (extensive metabolizers); ~96% (poor metabolizers) (1)
pregnancy:
Category C (1)
legal:
Rx-only in US (1)

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