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Medicines > fda max: Aspirin GI/bleeding-limited; oxycodone titrated to effect & duration: 4-6 hours

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generic:
Oxycodone / Aspirin (1)
brand:
Percodan (1)
classes:
[[:Category:Fixed-dose_combinations|Fixed-dose combination]] (1) · [[:Category:NSAIDs|NSAID (aspirin)]] (1) · [[:Category:Opioid_analgesics|Opioid analgesic]] (1) · [[:Category:Schedule_II_controlled_substances|Schedule II controlled substance]] (1)
mechanism:
'"`UNIQ--vote-000014F7-QINU`"' Falling out of favor for acute pain due to aspirin's GI bleeding and antiplatelet effects compared with acetaminophen-opioid combinations; still used in selected indications'"`UNIQ--ref-000014F8-QINU`"'. (1)
uses:
'"`UNIQ--vote-000014F9-QINU`"' (1)
starting dose:
1 tablet (4.8355 mg oxycodone / 325 mg aspirin) PO every 6 hours as needed (1)
preparations:
4.8355 mg oxycodone / 325 mg aspirin tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
15-30 minutes (1)
duration: (Click arrow to add another value)
halflife:
Oxycodone 3-5 hours; aspirin (acetyl group) 15-20 minutes, salicylate 2-3 hours at therapeutic doses'"`UNIQ--ref-000014FA-QINU`"' (1)
bioavailability:
Oxycodone 60-87%; aspirin 50-75%'"`UNIQ--ref-000014FB-QINU`"' (1)
pregnancy:
Avoid; aspirin teratogenicity concerns plus opioid neonatal withdrawal.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Schedule II|Schedule II controlled substance]] in US (1)

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