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Medicines > fda max : TID per eye or ~480 mg/d (oral); IV per protocol & duration: 8-12 hours (TID dosing needed)

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generic:
Dorzolamide (1)
brand:
Trusopt; with timolol as Cosopt (1)
classes:
[[:Category:Carbonic_anhydrase_inhibitors|Carbonic anhydrase inhibitor (topical)]] (1) · [[:Category:Glaucoma_medications|Glaucoma medication]] (1) · [[:Category:Ocular_hypotensive_agents|Ocular hypotensive agent]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000B08-QINU`"', '"`UNIQ--vote-00000B09-QINU`"' (1)
starting dose:
1 drop in affected eye(s) TID (monotherapy); BID with timolol (Cosopt) (1)
preparations:
2% ophthalmic solution (Trusopt); 2%/0.5% fixed combination with timolol (Cosopt, Cosopt PF) (1)
fda max: (Click arrow to add another value)
routes:
Topical ophthalmic (1)
onset:
IOP lowering at 2 hours; max at 4 hours (1)
duration: (Click arrow to add another value)
halflife:
~4 months in erythrocytes (carbonic anhydrase binding in red cells; not relevant to topical IOP duration)'"`UNIQ--ref-00000B0A-QINU`"' (1)
bioavailability:
Topical with measurable systemic absorption (small CA inhibition observed clinically with chronic use)'"`UNIQ--ref-00000B0B-QINU`"' (1)
pregnancy:
Limited data; weigh against alternatives.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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