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Medicines > fda max : 20 mg/d or 42 mg/d & duration: Daily dosing

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generic:
None (2)
brand:
Caplyta (1) · Trintellix (US), Brintellix (formerly) (1)
classes:
5HT2A/D2 antagonist with proposed differential pre/post-synaptic D2 activity (1) · Atypical antipsychotic (1) · Multimodal antidepressant: SERT inhibitor + 5HT1A agonist + 5HT1B partial agonist + 5HT3/5HT7 antagonist (1)
mechanism:
None (2)
uses:
Major depressive disorder in adults (FDA-approved 2013). Notable for evidence of cognitive benefit (processing speed) that distinguishes it from other antidepressants. (1) · Schizophrenia (FDA-approved Dec 2019). Bipolar depression as monotherapy or adjunct to lithium/valproate (FDA-approved Dec 2021). (1)
starting dose:
10 mg PO once daily; may increase to 20 mg as tolerated, or decrease to 5 mg if needed (1) · 42 mg PO once daily with food (no titration) (1)
preparations:
42 mg capsules (1) · 5 mg, 10 mg, 20 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (2)
onset:
Antipsychotic effect over weeks (1) · Typical antidepressant 4-6 week onset (1)
duration: (Click arrow to add another value)
halflife:
~18 hours (terminal) (1) · ~66 hours (1)
bioavailability:
Limited but adequate; take with food (1) · ~75% (1)
pregnancy:
Limited data; National Pregnancy Registry for Atypical Antipsychotics (1) · Limited data; weigh benefits/risks (1)
legal:
Rx (2)

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