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Medicines > routes : IV/IM (Buprenex). Oral swallowed: very low bioavailability due to first-pass; not therapeutic. or subcutaneous & duration: Monthly dosing

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generic:
None (2)
brand:
Aimovig (1) · Emgality (1)
classes:
Anti-CGRP ligand monoclonal antibody (1) · Anti-CGRP receptor monoclonal antibody (1)
mechanism:
Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Preventive treatment of migraine in adults (episodic and chronic) (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
70 mg SC monthly; may increase to 140 mg monthly (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
120 mg/mL prefilled syringe or autoinjector (1) · 70 mg/mL or 140 mg/mL prefilled autoinjector (1)
fda max:
140 mg/month (1) · 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster (1)
routes: (Click arrow to add another value)
onset:
Onset of preventive effect over weeks; some patients respond after first dose (1) · Over weeks (1)
duration: (Click arrow to add another value)
halflife:
~27 days (1) · ~28 days (1)
bioavailability:
Not formally established (high SC) (1) · ~82% SC (1)
pregnancy:
Limited data; avoid (2)
legal:
Rx (2)

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