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Drilldown: Medicines

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Medicines > fda max : 10 mg/d (adults) or Topical: nightly; systemic: regimen-specific & duration: N/A

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generic:
Fluorouracil (5-FU) (1)
brand:
Efudex (topical), Carac (topical), Fluoroplex (topical); generic IV (1)
classes:
[[:Category:Antimetabolites|Antimetabolite (pyrimidine analog)]] (1) · [[:Category:Antineoplastics|Antineoplastic]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-000011BA-QINU`"', '"`UNIQ--vote-000011BB-QINU`"', '"`UNIQ--vote-000011BC-QINU`"', '"`UNIQ--vote-000011BD-QINU`"' (1)
starting dose:
Topical: 0.5-5% cream/solution to lesions BID × 2-4 weeks; systemic IV: regimen-specific in cancer chemotherapy (1)
preparations:
0.5% (Carac), 1% (Fluoroplex), 5% (Efudex) topical creams/solutions; 50 mg/mL IV (1)
fda max: (Click arrow to add another value)
routes:
IV (1) · Topical (1)
onset:
Topical: inflammation, erythema, crusting at 2 weeks; complete response weeks to months after course (1)
duration: (Click arrow to add another value)
halflife:
~10-20 minutes systemically (rapid hepatic and erythrocyte dihydropyrimidine dehydrogenase clearance)'"`UNIQ--ref-000011BE-QINU`"' (1)
bioavailability:
Topical: minimal systemic absorption (oral systemic 5-FU not used due to poor and variable absorption)'"`UNIQ--ref-000011BF-QINU`"' (1)
pregnancy:
Topical: avoid; systemic: contraindicated in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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