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Medicines (732)

Medicines > generic: Spironolactone

& duration: Variable; biologically active metabolite carries effect beyond plasma half-life

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Aldactone, CaroSpir (1)

[[:Category:Aldosterone_antagonists|Mineralocorticoid (aldosterone) receptor antagonist]] (1) · [[:Category:Antiandrogens|Antiandrogen]] (1) · [[:Category:Potassium-sparing_diuretics|Potassium-sparing diuretic]] (1)

None (1)

'"`UNIQ--vote-0000034F-QINU`"', '"`UNIQ--vote-00000350-QINU`"', '"`UNIQ--vote-00000351-QINU`"', '"`UNIQ--vote-00000352-QINU`"', '"`UNIQ--vote-00000353-QINU`"' (1)

25 mg PO once daily for HFrEF and primary aldosteronism; up to 100 mg/d for ascites; 50-200 mg/d for hirsutism (1)

25 mg, 50 mg, 100 mg tablets; 25 mg/5 mL oral suspension (CaroSpir) (1)

400 mg/d (acute primary aldosteronism diagnosis); 100-200 mg/d typical chronic (1)

Oral (1)

Natriuresis at 2-3 days; endocrine effects (gynecomastia, antiandrogen action) over weeks (1)

1.4 hours (parent); 13-24 hours for active metabolite canrenone'"`UNIQ--ref-00000354-QINU`"' (1)

~70% (oral; bioavailability and absorption are improved with food)'"`UNIQ--ref-00000355-QINU`"' (1)

Avoid in pregnancy; antiandrogen effects can feminize a male fetus.<sup class="pcp-cn" title="This claim needs a citation.">[[[Pharmacopedia:Citation needed|citation needed]]]</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US (1)

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S

Spironolactone

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