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Medicines (732)

Medicines > generic

: Bumetanide

or None

& duration: ~12 weeks

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Botox (1)

neuromuscular blocker (presynaptic) (1) · Neurotoxin (1)

Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors (1)

Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic problems (1)

Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks (1)

50, 100, or 200 unit vials of lyophilized powder for reconstitution (1)

195 units/treatment for chronic migraine; max varies by problem (1)

Intramuscular (PREEMPT injections for migraine) (1)

1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles (1)

Tissue half-life not formally measured; clinical effect ~12 weeks (1)

Local (intramuscular) (1)

Category C; limited data (1)

Rx; black-box warning for distant spread of toxin effect (1)

Showing below up to 1 result in range #1 to #1.

O

Onabotulinumtoxin A

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