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Drilldown: Medicines

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Medicines > fda max : 10 mg/d or Titrated to glucose; no fixed maximum & onset: Glycosuria within hours; HbA1c effect at 12 weeks; CV/renal benefits over months

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generic:
Dapagliflozin (1)
brand:
Farxiga (US), Forxiga (international) (1)
classes:
[[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] (1) · [[:Category:Heart_failure_medications|Heart failure medication]] (1) · [[:Category:SGLT2_inhibitors|SGLT2 inhibitor]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000054E-QINU`"', '"`UNIQ--vote-0000054F-QINU`"', '"`UNIQ--vote-00000550-QINU`"', '"`UNIQ--vote-00000551-QINU`"' (1)
starting dose:
10 mg PO once daily in the morning; 5 mg starting in heart failure (1)
preparations:
5 mg, 10 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24 hours (1)
halflife:
~12.9 hours'"`UNIQ--ref-00000552-QINU`"' (1)
bioavailability:
~78% (oral; high-fat meal modestly reduces but is not clinically significant)'"`UNIQ--ref-00000553-QINU`"' (1)
pregnancy:
Avoid in second and third trimesters; fetal SGLT2 inhibition disrupts kidney development.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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