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Medicines > fda max : 10 mg/d (5 mg if severe renal or moderate hepatic impairment, or strong CYP3A4 inhibitors) or 100 mg/d & halflife: ~12.4 hours'"`UNIQ--ref-00000765-QINU`"'

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generic:
Sitagliptin (1)
brand:
Januvia; with metformin Janumet/Janumet XR (1)
classes:
[[:Category:Antihyperglycemic_agents|Antihyperglycemic agent]] (1) · [[:Category:DPP-4_inhibitors|DPP-4 inhibitor]] (1) · [[:Category:Incretin_modulators|Incretin pathway modulator]] (1)
mechanism:
'"`UNIQ--vote-00000762-QINU`"' Largely renally cleared, hence the eGFR-tiered dosing. Rare but well-documented signals: acute pancreatitis (uncertain causal contribution), severe joint pain, and bullous pemphigoid (class effect, especially in older Asian patients)'"`UNIQ--ref-00000763-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000764-QINU`"' (1)
starting dose:
100 mg PO once daily (50 mg if CrCl 30-44; 25 mg if <30 or dialysis) (1)
preparations:
25, 50, 100 mg tablets; combination tablets with metformin (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
Postprandial glucose effect within days; HbA1c by 12 weeks (1)
duration:
24 hours (1)
halflife: (Click arrow to add another value)
bioavailability:
~87% (oral)'"`UNIQ--ref-00000766-QINU`"' (1)
pregnancy:
Limited data; switch to insulin where feasible.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)
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