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Medicines > fda max : 10 mg/d (adults) or 120 mg/d (ER); IR not for chronic hypertension & routes: Oral; sublingual IR is discouraged (uncontrolled BP drops

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generic:
Nifedipine (1)
brand:
Procardia, Procardia XL, Adalat CC, Afeditab CR (1)
classes:
[[:Category:Antianginals|Antianginal]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1) · [[:Category:Calcium_channel_blockers|Calcium channel blocker (dihydropyridine)]] (1) · [[:Category:Tocolytics|Tocolytic (off-label)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"', '"`UNIQ--vote-00000749-QINU`"', '"`UNIQ--vote-0000074A-QINU`"', '"`UNIQ--vote-0000074B-QINU`"', '"`UNIQ--vote-0000074C-QINU`"' (1)
starting dose:
ER 30-60 mg PO once daily; immediate-release 10 mg PO TID (now rarely used for hypertension due to reflex tachycardia) (1)
preparations:
10, 20 mg IR capsules; 30, 60, 90 mg ER tablets (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
IR 20 minutes; ER ~6 hours (1)
duration:
IR 4-8 hours; ER 24 hours (1)
halflife:
2-5 hours (IR); ER formulations extend functional duration via osmotic/matrix release'"`UNIQ--ref-0000074D-QINU`"' (1)
bioavailability:
~50% IR (extensive first-pass via CYP3A4); ER products release-rate-limited'"`UNIQ--ref-0000074E-QINU`"' (1)
pregnancy:
Oral nifedipine is one of the preferred agents for severe hypertension in pregnancy and for tocolysis in preterm labor.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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