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Medicines > generic: Cetirizine & fda max : 10 mg/d (adults) or 16 mg/day (schizophrenia, adult); 6 mg/day (bipolar maintenance, autism irritability)

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generic: (Click arrow to add another value)
brand:
Zyrtec, Zyrtec-D (1)
classes:
[[:Category:Antihistamines|Antihistamine]] (1) · [[:Category:H1_receptor_antagonists|Histamine H1 receptor antagonist (second-generation)]] (1)
mechanism:
'"`UNIQ--vote-00000391-QINU`"' Minimal CYP metabolism; mostly renally cleared unchanged. Cetirizine is the active racemate; levocetirizine is the active R-enantiomer marketed separately'"`UNIQ--ref-00000392-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000393-QINU`"', '"`UNIQ--vote-00000394-QINU`"', '"`UNIQ--vote-00000395-QINU`"' (1)
starting dose:
10 mg PO once daily (5 mg in older adults or if sedation occurs) (1)
preparations:
5 mg, 10 mg tablets; 5 mg, 10 mg chewables; 1 mg/mL oral syrup; OTC (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
30-60 minutes (1)
duration:
24 hours (1)
halflife:
8-10 hours (longer in elderly and renal impairment)'"`UNIQ--ref-00000396-QINU`"' (1)
bioavailability:
High (oral); not significantly affected by food'"`UNIQ--ref-00000397-QINU`"' (1)
pregnancy:
Generally considered safe; widely used. Levocetirizine (the R-enantiomer) is an alternative with similar safety.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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