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Medicines > generic: Loratadine & fda max : 10 mg/d (adults) or 4 mg/d (schizophrenia); 3 mg/d (AD agitation); 3 mg/d (MDD adjunct)

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generic: (Click arrow to add another value)
brand:
Claritin, Alavert, Tavist ND (1)
classes:
[[:Category:Antihistamines|Antihistamine]] (1) · [[:Category:H1_receptor_antagonists|Histamine H1 receptor antagonist (second-generation)]] (1)
mechanism:
'"`UNIQ--vote-0000061E-QINU`"' Less reliably anticholinergic than first-generation H1s; minimal antiemetic effect. Desloratadine (Clarinex) is the active enantiomer-of-metabolite version marketed as a Rx alternative. (1)
uses:
'"`UNIQ--vote-0000061F-QINU`"', '"`UNIQ--vote-00000620-QINU`"' (1)
starting dose:
10 mg PO once daily (1)
preparations:
10 mg tablets; 5 mg ODT and chewables; 1 mg/mL oral syrup; combo Claritin-D (with pseudoephedrine, behind-counter) (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
1-3 hours (slower onset than cetirizine; symptom relief somewhat less) (1)
duration:
24 hours (1)
halflife:
~8 hours (parent); ~28 hours (desloratadine, the active metabolite, marketed separately as Clarinex)'"`UNIQ--ref-00000621-QINU`"' (1)
bioavailability:
High (oral; food prolongs absorption modestly)'"`UNIQ--ref-00000622-QINU`"' (1)
pregnancy:
Generally considered safe; widely used. Loratadine and cetirizine are the most-recommended 2nd-gen H1s in pregnancy and lactation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (1)

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