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Medicines > fda max : 10 mg BID for the first 7 days of acute VTE; otherwise 5 mg BID or 400 mg/d & onset: Peak anticoagulant effect 3-4 hours

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generic:
Apixaban (1)
brand:
Eliquis (1)
classes:
[[:Category:Anticoagulants|Anticoagulant]] (1) · [[:Category:Direct_factor_Xa_inhibitors|Direct factor Xa inhibitor]] (1) · [[:Category:DOACs|Direct oral anticoagulant (DOAC)]] (1)
mechanism:
'"`UNIQ--vote-000001F6-QINU`"' CYP3A4 (primary) and P-glycoprotein substrate; strong dual inhibitors or inducers materially shift exposure. Reversal: andexanet alfa for life-threatening bleeding; 4F-PCC commonly used off-label when andexanet unavailable'"`UNIQ--ref-000001F7-QINU`"'. (1)
uses:
'"`UNIQ--vote-000001F8-QINU`"', '"`UNIQ--vote-000001F9-QINU`"', '"`UNIQ--vote-000001FA-QINU`"' (1)
starting dose:
NVAF: 5 mg PO BID (2.5 mg BID if 2 of 3: age ≥80, weight ≤60 kg, serum creatinine ≥1.5 mg/dL); acute VTE: 10 mg BID for 7 days, then 5 mg BID (1)
preparations:
2.5 mg, 5 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
12 hours (1)
halflife:
~12 hours'"`UNIQ--ref-000001FB-QINU`"' (1)
bioavailability:
~50% (oral; not significantly affected by food)'"`UNIQ--ref-000001FC-QINU`"' (1)
pregnancy:
None (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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