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Drilldown: Medicines

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Medicines > fda max : 100 mg/d or 80 mg/d & onset: LDL lowering at 2 weeks, max by 4 weeks; cardiovascular benefit months to years

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generic:
Atorvastatin (1)
brand:
Lipitor (1)
classes:
[[:Category:Lipid-lowering_agents|Lipid-lowering agent]] (1) · [[:Category:Statins|Statin]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"' (1)
starting dose:
10-20 mg PO once daily (1)
preparations:
10 mg, 20 mg, 40 mg, 80 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset: (Click arrow to add another value)
duration:
24-48 hours per dose (1)
halflife:
14 hours (parent); 20-30 hours including active ortho- and para-hydroxylated metabolites'"`UNIQ--ref-0000001B-QINU`"' (1)
bioavailability:
~14% (extensive hepatic first-pass)'"`UNIQ--ref-0000001C-QINU`"' (1)
pregnancy:
Previously Category X; FDA removed the blanket statin contraindication in pregnancy in 2021. Use individualized; lactation generally avoided.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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