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Medicines > generic: Losartan & fda max : 100 mg/d or ~2500 mg elemental/d combined diet + supplements (chronic; UL)

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generic: (Click arrow to add another value)
brand:
Cozaar (1)
classes:
[[:Category:Angiotensin_receptor_blockers|Angiotensin receptor blocker (ARB)]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1)
mechanism:
'"`UNIQ--vote-000000B6-QINU`"' Active metabolite EXP3174 is ~10-40-fold more potent than the parent and accounts for most of the antihypertensive effect; CYP2C9 polymorphism affects conversion'"`UNIQ--ref-000000B7-QINU`"'. (1)
uses:
'"`UNIQ--vote-000000B8-QINU`"', '"`UNIQ--vote-000000B9-QINU`"', '"`UNIQ--vote-000000BA-QINU`"', '"`UNIQ--vote-000000BB-QINU`"' (1)
starting dose:
50 mg PO daily (25 mg in volume depletion or hepatic impairment) (1)
preparations:
25 mg, 50 mg, 100 mg tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
BP effect 1-2 weeks; antihypertensive peak 3-6 weeks (1)
duration:
24 hours (1)
halflife:
2 hours (parent); 6-9 hours for active carboxylic acid metabolite EXP3174'"`UNIQ--ref-000000BC-QINU`"' (1)
bioavailability:
~33% (extensive first-pass via CYP2C9 and CYP3A4)'"`UNIQ--ref-000000BD-QINU`"' (1)
pregnancy:
'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, hypocalvaria, hypotension. Stop on detection'"`UNIQ--ref-000000BE-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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