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Medicines > generic: None & fda max : 2 tablets/day (dextromethorphan 90 mg / bupropion 210 mg) or 40 mg/d

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generic: (Click arrow to add another value)
brand:
Auvelity (dextromethorphan/bupropion ER) (1) · Viibryd (1)
classes:
NMDA receptor antagonist + sigma-1 agonist + NDRI (combination) (1) · Serotonin partial agonist reuptake inhibitor (SPARI) (1)
mechanism:
None (2)
uses:
Major depressive disorder in adults (FDA-approved 2011) (1) · Major depressive disorder in adults (FDA-approved August 2022) (1)
starting dose:
1 tablet (dextromethorphan 45 mg / bupropion 105 mg) PO daily × 3 days, then increase to 1 tablet BID (1) · 10 mg PO once daily × 7 days, then 20 mg × 7 days, then 40 mg as target dose (take with food) (1)
preparations:
10 mg, 20 mg, 40 mg tablets (1) · Dextromethorphan 45 mg + bupropion 105 mg ER tablets (1)
fda max: (Click arrow to add another value)
routes:
Oral (2)
onset:
4-6 weeks for full antidepressant effect (claimed earlier onset for some patients due to 5HT1A partial agonism) (1) · Significant antidepressant response by week 1 in trials (faster than monoaminergic antidepressants which take 4-6 weeks) (1)
duration:
Daily dosing (1) · Sustained with twice-daily dosing (1)
halflife:
Dextromethorphan ~22 h (when CYP2D6 inhibited); bupropion ~21 h (1) · ~25 hours (1)
bioavailability:
Not formally characterized for the combination (1) · ~72% (with food); much lower fasting (~36%) (1)
pregnancy:
Limited data; avoid (1) · Limited data; weigh benefits/risks (1)
legal:
Rx (2)

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