Jump to content

Drilldown: Medicines

Pharmacopedia
BrowseCategoriesLog in

Choose a table:


Medicines > fda max : 2 tablets/day (dextromethorphan 90 mg / bupropion 210 mg) or 50 mg/d & routes: oral

Use the filters below to narrow your results.

generic:
None (2) · Mirabegron (1)
brand:
Auvelity (dextromethorphan/bupropion ER) (1) · Myrbetriq (1) · Quviviq (1)
classes:
Dual orexin receptor antagonist (DORA) (1) · NMDA receptor antagonist + sigma-1 agonist + NDRI (combination) (1) · [[:Category:Beta-3_agonists|β3 adrenergic agonist]] (1) · [[:Category:Overactive_bladder_medications|Overactive bladder medication]] (1)
mechanism:
None (3)
uses:
Insomnia (sleep onset and/or sleep maintenance) in adults (FDA-approved Jan 2022) (1) · Major depressive disorder in adults (FDA-approved August 2022) (1) · '"`UNIQ--vote-00000C4C-QINU`"', '"`UNIQ--vote-00000C4D-QINU`"' (1)
starting dose:
1 tablet (dextromethorphan 45 mg / bupropion 105 mg) PO daily × 3 days, then increase to 1 tablet BID (1) · 25 mg PO at bedtime (no titration); may increase to 50 mg if 25 mg inadequate (1) · 25 mg PO once daily; titrate to 50 mg after 4-8 weeks if needed (1)
preparations:
25 mg, 50 mg tablets (1) · 25, 50 mg ER tablets; 8 mg/mL granules for oral suspension (Myrbetriq Granules, pediatric) (1) · Dextromethorphan 45 mg + bupropion 105 mg ER tablets (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Significant antidepressant response by week 1 in trials (faster than monoaminergic antidepressants which take 4-6 weeks) (1) · Symptom improvement within weeks (1) · ~30 min (1)
duration:
24 hours (1) · Sustained with twice-daily dosing (1) · ~7-8 hours (1)
halflife:
Dextromethorphan ~22 h (when CYP2D6 inhibited); bupropion ~21 h (1) · ~50 hours'"`UNIQ--ref-00000C4E-QINU`"' (1) · ~8 hours (shorter than suvorexant and lemborexant) (1)
bioavailability:
25 mg: ~29%; 50 mg: ~35%; food reduces absorption'"`UNIQ--ref-00000C4F-QINU`"' (1) · Not formally characterized for the combination (1) · ~62% (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Limited data; avoid (2)
legal:
Rx (1) · Rx, Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

Showing below up to 3 results in range #1 to #3.

View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)


View (previous 250 | next 250) (20 | 50 | 100 | 250 | 500)

Retrieved from "https://pharmacopedia.wiki/p/Special:Drilldown/Medicines"