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Medicines > fda max : 240 mg/d (mononitrate ER); 160 mg/d (dinitrate) or 40 mg/d typical; up to 240 mg/d for Zollinger-Ellison & routes: sublingual (dinitrate)

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generic:
Isosorbide (dinitrate, mononitrate) (1)
brand:
Imdur (mononitrate ER), Isordil (dinitrate); generics; with hydralazine as BiDil for HFrEF in self-identified Black patients (1)
classes:
[[:Category:Antianginals|Antianginal]] (1) · [[:Category:Nitrates|Organic nitrate]] (1) · [[:Category:Vasodilators|Vasodilator]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000145E-QINU`"', '"`UNIQ--vote-0000145F-QINU`"', '"`UNIQ--vote-00001460-QINU`"' (1)
starting dose:
Isosorbide mononitrate ER: 30-60 mg PO once daily in the morning, titrate to 120-240 mg/d; isosorbide dinitrate IR: 5-20 mg PO TID with a 12-14 hour nitrate-free interval to prevent tolerance (1)
preparations:
Mononitrate 10, 20 mg IR; 30, 60, 120 mg ER; dinitrate 5, 10, 20, 30, 40 mg IR and ER (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
SL: 2-5 minutes; PO mononitrate: 30-60 minutes (1)
duration:
Mononitrate ER: 12-24 hours; dinitrate IR: 4-6 hours (1)
halflife:
Mononitrate ~5 hours; dinitrate ~1 hour'"`UNIQ--ref-00001461-QINU`"' (1)
bioavailability:
Mononitrate ~100% (no first-pass; the principal advantage over dinitrate); dinitrate ~20%'"`UNIQ--ref-00001462-QINU`"' (1)
pregnancy:
Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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