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Medicines > generic: None & fda max : 240 mg loading + 120 mg/month for migraine; 300 mg/month for cluster or 40 mg/d

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generic: (Click arrow to add another value)
brand:
Emgality (1) · Viibryd (1)
classes:
Anti-CGRP ligand monoclonal antibody (1) · Serotonin partial agonist reuptake inhibitor (SPARI) (1)
mechanism:
None (1) · Humanized IgG4 monoclonal antibody binding CGRP peptide; prevents CGRP from activating its receptor (1)
uses:
Major depressive disorder in adults (FDA-approved 2011) (1) · Preventive treatment of migraine in adults; episodic cluster headache (1)
starting dose:
10 mg PO once daily × 7 days, then 20 mg × 7 days, then 40 mg as target dose (take with food) (1) · Migraine: 240 mg SC loading dose, then 120 mg SC monthly. Cluster: 300 mg SC at onset of cluster period, then monthly during cluster. (1)
preparations:
10 mg, 20 mg, 40 mg tablets (1) · 120 mg/mL prefilled syringe or autoinjector (1)
fda max: (Click arrow to add another value)
routes:
Oral (1) · Subcutaneous (1)
onset:
4-6 weeks for full antidepressant effect (claimed earlier onset for some patients due to 5HT1A partial agonism) (1) · Over weeks (1)
duration:
Daily dosing (1) · Monthly dosing (1)
halflife:
~25 hours (1) · ~27 days (1)
bioavailability:
Not formally established (high SC) (1) · ~72% (with food); much lower fasting (~36%) (1)
pregnancy:
Limited data; avoid (1) · Limited data; weigh benefits/risks (1)
legal:
Rx (2)

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