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Medicines > generic: Butalbital / Acetaminophen / Caffeine & fda max : 4 g/d or 6 capsules/d (300 mg butalbital, 1950 mg acetaminophen, 240 mg caffeine)

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generic: (Click arrow to add another value)
brand:
Fioricet, Esgic; with codeine as Fioricet with Codeine (Schedule III) (1)
classes:
[[:Category:Barbiturates|Barbiturate (butalbital)]] (1) · [[:Category:Fixed-dose_combinations|Fixed-dose combination]] (1) · [[:Category:Methylxanthines|Methylxanthine (caffeine)]] (1) · [[:Category:Non-opioid_analgesics|Non-opioid analgesic (acetaminophen)]] (1)
mechanism:
None (1)
uses:
'"`UNIQ--vote-0000159D-QINU`"', '"`UNIQ--vote-0000159E-QINU`"' (1)
starting dose:
1-2 capsules (50 mg butalbital / 325 mg acetaminophen / 40 mg caffeine each) PO every 4 hours as needed; maximum 6 capsules/d (1)
preparations:
50/325/40 mg capsules and tablets; oral solution (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
30-60 minutes (1)
duration:
4-6 hours (1)
halflife:
Butalbital ~35 hours (long; cumulative effects with frequent use); acetaminophen 1-3 hours; caffeine 3-7 hours'"`UNIQ--ref-0000159F-QINU`"' (1)
bioavailability:
Butalbital well-absorbed; caffeine ~100%; acetaminophen 85-98%'"`UNIQ--ref-000015A0-QINU`"' (1)
pregnancy:
Generally avoided; barbiturate exposure in late pregnancy can produce neonatal withdrawal and respiratory depression.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (1)

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