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Medicines > generic: Lisinopril & fda max : 40 mg/d (rarely needed; 40 mg restricted to patients not at goal on 20 mg) or 80 mg/d

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generic: (Click arrow to add another value)
brand:
Zestril, Prinivil, Qbrelis (1)
classes:
[[:Category:ACE_inhibitors|ACE inhibitor]] (1) · [[:Category:Antihypertensives|Antihypertensive]] (1)
mechanism:
'"`UNIQ--vote-00000053-QINU`"' Also raises bradykinin, contributing to vasodilation and the characteristic dry cough. Renally cleared, unmetabolized; dose-adjust by eGFR'"`UNIQ--ref-00000054-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000055-QINU`"', '"`UNIQ--vote-00000056-QINU`"', '"`UNIQ--vote-00000057-QINU`"', '"`UNIQ--vote-00000058-QINU`"' (1)
starting dose:
5-10 mg PO once daily (2.5 mg in heart failure, hyponatremia, or volume depletion) (1)
preparations:
2.5, 5, 10, 20, 30, 40 mg tablets; 1 mg/mL oral solution (1)
fda max: (Click arrow to add another value)
routes:
Oral (1)
onset:
BP lowering within 1 hour; max effect at 6 hours (1)
duration:
24 hours (1)
halflife:
~12 hours (effective); terminal half-life is biphasic'"`UNIQ--ref-00000059-QINU`"' (1)
bioavailability:
~25% (oral; food does not affect absorption)'"`UNIQ--ref-0000005A-QINU`"' (1)
pregnancy:
'''Contraindicated in pregnancy''' (all trimesters); fetal renal injury, oligohydramnios, skull hypoplasia, hypotension. Stop on detection'"`UNIQ--ref-0000005B-QINU`"' (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US (1)

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