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Medicines > fda max : 400 mg/d or ~480 mg/d (oral) for cardiovascular indications; higher off-label for cluster & routes: Topical ophthalmic

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generic:
Moxifloxacin (1)
brand:
Avelox (oral/IV brand discontinued US); Vigamox, Moxeza (ophthalmic) (1)
classes:
[[:Category:Antibacterials|Antibacterial]] (1) · [[:Category:Fluoroquinolones|Fluoroquinolone antibiotic]] (1)
mechanism:
'"`UNIQ--vote-00000D7A-QINU`"' Substantial QT-interval prolongation — the most QT-prolonging fluoroquinolone — limits use in patients on other QT-prolonging agents or with electrolyte abnormalities'"`UNIQ--ref-00000D7B-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000D7C-QINU`"', '"`UNIQ--vote-00000D7D-QINU`"', '"`UNIQ--vote-00000D7E-QINU`"', '"`UNIQ--vote-00000D7F-QINU`"', '"`UNIQ--vote-00000D80-QINU`"', '"`UNIQ--vote-00000D81-QINU`"' (1)
starting dose:
400 mg PO/IV once daily (1)
preparations:
400 mg tablets; 400 mg/250 mL IV; 0.5% ophthalmic solution (1)
fda max: (Click arrow to add another value)
routes: (Click arrow to add another value)
onset:
Hours (1)
duration:
24 hours (1)
halflife:
~12 hours'"`UNIQ--ref-00000D82-QINU`"' (1)
bioavailability:
~90% (oral; not affected by food but reduced by divalent cations)'"`UNIQ--ref-00000D83-QINU`"' (1)
pregnancy:
'''Avoid in pregnancy where alternatives exist''' (animal cartilage toxicity).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
[[USLegal:Prescription only|Rx-only]] in US. Carries the same fluoroquinolone-class '''Boxed Warnings''' as ciprofloxacin/levofloxacin'"`UNIQ--ref-00000D84-QINU`"' (1)

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